By Flossie Wong-Staal, Robert C. Gallo
This reference describes the newest advances within the improvement and layout of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV an infection for the development of molecular and healing ideas to lessen the development and transmission of AIDS. With contributions by way of universally famous experts within the box, AIDS Vaccine study discusses
Read or Download AIDS Vaccine Research PDF
Similar hematology books
Hematopoietic stem mobilephone transplantation (HSCT) is at present applied as a therapy choice for numerous life-threatening stipulations affecting childrens and teens together with leukemia, lymphoma, neuroblastoma, mind tumors, inherited immune deficiency syndromes, blood problems, and inherited metabolic illnesses.
It is a 3-in-1 reference ebook. It supplies an entire scientific dictionary protecting 1000's of phrases and expressions in relation to hematoma. It additionally provides wide lists of bibliographic citations. ultimately, it presents details to clients on how one can replace their wisdom utilizing quite a few net assets.
This complete reference on histiocytic issues considers the genetics, pathophysiology, and medical administration of this wide selection of illnesses. It covers all points of hystiocytic disorders--from Langerhans mobile histiocytosis and hemophagocytic lymphohistiocytosis, to the unusual cutaneous and extracutaneous histiocytic issues.
There are few courses approximately drug interactions in chemotherapy or even much less approximately pediatric oncology remedy. hence, the current e-book is meant to provide directions approximately drug interactions for physicians, pharmacists and the opposite healthcare execs occupied with the chemotherapy of pediatric sufferers.
- Myelodysplastic Syndromes: Pathobiology and Clinical Management
- The Welfare of Sheep
- Understanding Leukemias, Lymphomas and Myelomas, Second Edition
- Platelets, Third Edition
- New therapeutic agents in thrombosis and thrombolysis
- The Clinical Practice of Stem-Cell Transplantation (2 Volume Set)
Extra resources for AIDS Vaccine Research
Impaired accessory cell function (517,518) may result from decreased MHC class II expression, decreased IL-12 secretion, and increased IL-10 secretion (518,519); this HIV-induced dysregulation of antigen presentation may in turn be a signiﬁcant cause of hyporesponsiveness of CD4ϩ T cells (502,517). Defects in ADCC function of monocyte/macrophages, possibly related to low levels of expression of Fc and complement receptors, have also been observed in HIV infection (520–522). Finally, HIV-associated abnormalities in antigen uptake, oxidative burst, and chemotaxis have been described in monocyte/macrophages (519,523–526).
Although the immune system is capable of efﬁcient elimination of a substantial number of productively infected cells in lymphoid tissue, the very earliest interactions between virus and host virtually ensure viral persistence. In this regard, massive numbers of virions trapped within the germi- 20 Cohen and Fauci nal center FDC network as well as latently infected cells, which harbor proviral DNA but do not express viral proteins (and thus elude the immune response), represent potentially continuous sources of virus for de novo infection of CD4ϩ T lymphocytes that are resident in or migrating through lymphoid tissue (138– 142).
13. 14. 15. 16. 17. 41 cofactors determine human immunodeﬁciency virus type 1 tropism for Tcell lines versus primary macrophages. J Virol 70:5487–5494. , A. DeVico, A. Garzino-Demo, S. Arya, R. Gallo, P. Lusso. 1995. Identiﬁcation of RANTES, MIP-1α, and MIP-1β as the major HIV suppressive factors produced by CD8ϩ T cells. Science 270:1811–1815. , C. Broder, P. Kennedy, E. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane domain, G-protein coupled receptor. Science 272:872–877.
AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo