AIDS Vaccine Research - download pdf or read online

By Flossie Wong-Staal, Robert C. Gallo

ISBN-10: 0585403627

ISBN-13: 9780585403625

ISBN-10: 0824706455

ISBN-13: 9780824706456

This reference describes the newest advances within the improvement and layout of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV an infection for the development of molecular and healing ideas to lessen the development and transmission of AIDS. With contributions by way of universally famous experts within the box, AIDS Vaccine study discusses

  • major hindrances within the identity of a preventive vaccine
  • the function of innate immunity in administration of HIV an infection
  • the effect of hugely lively antiretroviral remedy (HAART) on AIDS learn
  • the construction of an efficient mucosal DNA vaccine
  • the impression of the AIDS epidemic on constructing international locations providing approximately 2000 modern references to facilitate additional examine, AIDS Vaccine study is a well timed handbook appropriate for immunologists, virologists, pathologists, epidemiologists, pharmacologists, microbiologists, hematologists, hepatologists, AIDS researchers, and upper-level undergraduate and graduate scholars in those disciplines.
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    Extra resources for AIDS Vaccine Research

    Example text

    Impaired accessory cell function (517,518) may result from decreased MHC class II expression, decreased IL-12 secretion, and increased IL-10 secretion (518,519); this HIV-induced dysregulation of antigen presentation may in turn be a significant cause of hyporesponsiveness of CD4ϩ T cells (502,517). Defects in ADCC function of monocyte/macrophages, possibly related to low levels of expression of Fc and complement receptors, have also been observed in HIV infection (520–522). Finally, HIV-associated abnormalities in antigen uptake, oxidative burst, and chemotaxis have been described in monocyte/macrophages (519,523–526).

    Although the immune system is capable of efficient elimination of a substantial number of productively infected cells in lymphoid tissue, the very earliest interactions between virus and host virtually ensure viral persistence. In this regard, massive numbers of virions trapped within the germi- 20 Cohen and Fauci nal center FDC network as well as latently infected cells, which harbor proviral DNA but do not express viral proteins (and thus elude the immune response), represent potentially continuous sources of virus for de novo infection of CD4ϩ T lymphocytes that are resident in or migrating through lymphoid tissue (138– 142).

    13. 14. 15. 16. 17. 41 cofactors determine human immunodeficiency virus type 1 tropism for Tcell lines versus primary macrophages. J Virol 70:5487–5494. , A. DeVico, A. Garzino-Demo, S. Arya, R. Gallo, P. Lusso. 1995. Identification of RANTES, MIP-1α, and MIP-1β as the major HIV suppressive factors produced by CD8ϩ T cells. Science 270:1811–1815. , C. Broder, P. Kennedy, E. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane domain, G-protein coupled receptor. Science 272:872–877.

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    AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo


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