Novartis Foundation's Ageing Vulnerability: Causes and Interventions: Novartis PDF

By Novartis Foundation

ISBN-10: 0470868694

ISBN-13: 9780470868690

ISBN-10: 0471494380

ISBN-13: 9780471494386

With the ever-increasing upward thrust in lifestyles expectancy, there's an pressing have to enhance our knowing of the connection among getting older and the pathogenesis of age-related ailments so one can determine more beneficial technique of prevention, amelioration and administration of such ailments. furthermore, there's a have to decrease the social and monetary impression of the growing old inhabitants. Age-related morbidity and mortality vary dramatically between contributors; this booklet focusses on person ameliorations in susceptibility to age-related problems.

It comprises contributions from best specialists within the box on themes such as:
age-related pathology within the mind, age-related techniques in stem cells, and age-related results at the immune approach and in bone, muscle and cardiovascular tissue. For all people with an curiosity within the biology of growing old, this is often obligatory reading.Content:

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Neurology 42:1702^1706 Pearson SJ, Reynolds GP 1992 Increased brain concentrations of a neurotoxin, 3hydroxykynurenine, in Huntington’s disease. Neurosci Lett 144:199^201 Racz P, Erdohelyi A 1988 Cadmium, lead and copper concentrations in normal and senile cataractous human lenses. Ophthalmic Res 20:3^10 Rae TD, Schmidt PJ, Pufahl RA, Culotta VC, O’Halloran TV 1999 Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase. Science 284:805^808 Ramachandran S, Morris SM, Devamanoharan P, Henein M, Varma SD 1991 Radio-isotopic determination of hydrogen peroxide in aqueous humor and urine.

Bush: We do use them up. This is where the protein slowly oligomerizes. It appears that the donating groups are methionine and tyrosine, and possibly also histidine. The molecule in fact o¡ers lots of electrons. We are just trying to ¢gure out which residues go ¢rst and which are the most important. Halliwell: Suppose it is tyrosine, and you make tyrosine radicals that dimerize. g. with glutathione. What happens in your system if you put in biological reducing agents such as ascorbate and glutathione?

Secondly, the proposed reactions may be carried out in the local environment of the protein-bound metal. An increase in free redox-active metal ions in the lens may not be obligatory for these reactions to occur, as mentioned above. These mechanisms may not be mutually exclusive. Interestingly, kynurenine pathway catabolites have been implicated in a variety of neurodegenerative, in£ammatory and immunological phenomena including Huntington’s disease (Reynolds & Pearson 1989, Pearson & Reynolds 1992), Parkinson’s disease (Ogawa et al 1992), HIV encephalopathy (Sardar et al 1995), 34 BUSH & GOLDSTEIN cerebral malaria (Sanni et al 1998), poliomyelitis (Heyes et al 1992, 1993) and fetomaternal tolerance (Munn et al 1998).

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Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235 by Novartis Foundation


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