By D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD
A well known crew of retina surgeons offers promising new advancements in age-related macular degeneration, with emphasis at the most vital advances long ago 5 years. content material addresses all facets of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in age-related macular degeneration; prevention measures and remedy; remedy; and destiny instructions. Abundantly illustrated and fantastically equipped, this ebook serves as a great reference and textbook.
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Extra info for Age-related macular degeneration : a comprehensive textbook
Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells. Bichem Biophys Res Commun. 1987;143:934-940. 66. Baudouin C, Fred-Reygrobellet D, Carvelle J-P, et al. Acidic fibroblast growth factor distribution in normal human eye and possible implications in ocular pathogenesis. Ophthalmic Res. 1990;22:73-81. 67. Connolly SE, Hjelmeland LM, LaVail MM. Immunohistochemical localization of basic fibroblast growth factor in mature and developing retinas of normal and RCS rats.
A possible cause of CNV may be gleaned from the histopathologic observation of the deposition of basal laminar and basal linear deposit. The most common histopathologic correlate to soft drusen is the accumulation of membranous debris in basal linear deposit (56,57,63). Soft drusen are an ocular risk factor for the development of CNV in ARMD. There are several ways that deposited material may play a role in the development of CNV. It is possible that the presence of deposits, particularly lipids, affects the ability of growth factors produced by the RPE to diffuse through Bruch's membrane.
97. Orzalesi N, Migliavacca L, Miglior S. Subretinal neovascularization after naphthalene damage to the rabbit retina. Invest Ophthalmol Vis Sci. 1994;35:696-705. 98. Samkoe KS, Cramb DT. Application of an ex ovo chicken chorioallantoic membrane model for two-photon excitation photodynamic therapy of agerelated macular degeneration. J Biomed Optics. 2003;8:410-417. 99. Gottfired V, Davidi R, Acerbuj C, et al. In vivo damage to chorioallantoic membrane blood vessels by porphycene-induced photodynamic therapy.
Age-related macular degeneration : a comprehensive textbook by D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD