Download PDF by Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor): Acute Promyelocytic Leukemia: Molecular Genetics, Mouse

By Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)

ISBN-10: 3540345922

ISBN-13: 9783540345923

ISBN-10: 3540345949

ISBN-13: 9783540345947

Over the last 10 years, paintings on acute promyelocytic leukemia (APL) has develop into the paradigm of translational examine that started with the invention of a recurrent chromosomal translocation, by way of the id of the genes and proteins concerned, discovering their molecular features in transcriptional keep watch over, constructing mouse versions and culminating within the improvement  of detailed treatment.

Show description

Read or Download Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313) PDF

Best microbiology books

Get Microbiology DeMYSTiFieD (2nd Edition) PDF

<h4>Demystified is your vaccine for difficult matters like microbiology</h4>
If you don't understand your prokaryotes out of your protozoa, or studying approximately fungi places you in a funk, glance no further--Microbiology Demystified, moment variation is your treatment for studying this topic's primary ideas and theories at your personal pace.

This sensible consultant eases you into this box of technological know-how, beginning on the cellphone point. As you move, you'll grasp microbiology necessities corresponding to micro organism, algae, viruses, pasteurization, and extra. you are going to comprehend the adaptation among pleasant and unfriendly microorganisms in addition to the microscope's position in shaping microbiology. precise examples make it effortless to appreciate the fabric, and end-of-chapter quizzes and a last examination support make stronger key ideas.

It's a no brainer! You'll know about: * class of microorganisms * Immunology * Germ idea * Recombinant DNA expertise * Pathogens * E. coli * Antiseptics

Simple adequate for a newbie, yet difficult sufficient for a sophisticated pupil, Microbiology Demystified. moment version, is helping you grasp this crucial subject.

New PDF release: Microbes in Motion 3 CD-ROM

This interactive, easy-to-use common microbiology CD-ROM is helping scholars actively discover and comprehend microbial constitution and serve as via audio, video, animations, illustrations, and textual content. The CD is suitable for either majors and non-majors microbiology classes and is a cross-platform product, making it suitable with either home windows and Macs.

Bergey's Manual® of Systematic Bacteriology: The - download pdf or read online

Due to the fact that ebook of the 1st version of Bergey’s handbook of Systematic Bacteriology, it has turn into famous through the international because the crucial monographic paintings within the box of prokaryotic biology. Like a dictionary to a author, the guide is mostly the 1st reference microbiologist consults whilst questions come up in regards to the features of an surprising species or an unknown pressure that bears a few similarity to a extra standard one.

Download e-book for kindle: Microbial-Based Biopesticides: Methods and Protocols by Travis R. Glare, Maria E. Moran-Diez

This quantity makes a speciality of the developmental parts of biopesticides: creation, formula, software and box efficacy. Chapters consultant readers via tools and strategies on environmental, mammalian, protection, and registration.  Written within the hugely winning equipment in Molecular Biology sequence structure, chapters comprise introductions to their respective issues, lists of the mandatory fabrics and reagents, step by step, without problems reproducible laboratory protocols, and tips about troubleshooting and averting identified pitfalls.

Additional info for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313)

Sample text

J. McConnell · J. D. Licht PLZF-null mice do not exhibit an obvious hematopoietic phenotype, nor do they develop leukemia or other tumors. However, this does not rule out a role for PLZF in hematopoiesis. A second PLZF-like gene exists, which is expressed in a similar pattern during differentiation of hematopoietic progenitor cells. 1, suggesting that it arose by duplication of the PLZF-MLL locus at 11q23. The FAZF protein also has a BTB domain, and three Kruppel-like C2 H2 zinc fingers highly homologous to the final three DNA-binding zinc fingers of PLZF.

These findings also imply that PLZF and the related FAZF gene may be important for the proper control of growth and homeostasis of multiple tissues. Unresolved questions in regard to PLZF include its exact mode of repression, and key transcriptional targets and physiological stimuli that lead to its posttranslational modification and subsequent regulation of transcriptional function. References 1. 2. 3. 4. 5. 6. Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD (1999) The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase.

Furthermore, animal models of APL are equally important for assessing ideas regarding the value of novel therapies. As we learn more about APL, added questions are raised. Among the areas that animal models will be used for in the coming years are: 1. Developing a better understanding of the cells from which relapses arise in APL and other AMLs. ) 2. Identifying the critical transcriptional targets repressed by X-RARα proteins. 3. Elucidating effects on PML and its interaction partners that facilitate leukemic transformation.

Download PDF sample

Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313) by Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)

by Ronald

Rated 4.04 of 5 – based on 11 votes